Exemestane by Hilma Biocare is an antitumor agent and a steroidal Aromatase Inhibitor. Its structure is similar to the natural steroid hormone androstenedione. Like other Aromatase Inhibitors, Exemestane helps the body fight against cancer and tumors by providing anti-estrogenic protection.
It doesn't have any progestogenic or estrogenic activity, and it affects the biosynthesis of cortisol and aldosterone in the adrenal glands. Exemestane is widely used by steroid users during the cycle and PCT to suppress estrogen levels in the body up to 85% and protect against aromatization.
However, it should be noted that not all anabolic steroids are susceptible to aromatization. The use of Exemestane is justified for drugs like testosterone and its derivatives, methandrostenolone, and methyltestosterone. Boldenone and chalotestin are slightly aromatized.
Specifications:
- Active Half-life (Hours): 24h
- Group: Aromatase inhibitor
- Dosage: 25 mg/tab.
- Application (Men): 25 mg throughout 3 days
- Retains water: No
- Aromatization: No
In bodybuilding, aromatase inhibitors are used most often during an anabolic steroid cycle for:
- prevention of gynecomastia;
- increase in the level of anabolic hormones in the blood;
- increasing relief (by eliminating the negative effects of estrogen);
- prevention of hypertension;
- reducing estrogen suppression of the hypothalamic-pituitary-testicular axis, leading to faster recovery.
The use of exemestane during the course
The tactics of most domestic athletes are reduced to the use of aromatase inhibitors when the first signs of gynecomastia appear (swelling, itching in the nipples, redness). However, this approach is not optimal.
The most rational solution is to perform an estradiol analysis after about 10 days of taking anabolic steroids with a short half-life (testosterone propionate, methandrostenolone) or after 3-4 weeks of long esters (enanthate, Sustanon, cypionate). Then an average dosage of anastrozole 0.5 mg every other day is prescribed. After 10 days, a control analysis of estradiol is performed and the dosage is adjusted according to the results.
A compromise option would be the use of a moderate or low dosage of anastrozole with a focus on subjective sensations. If after the appointment there is a drop in libido, erectile dysfunction, or depression, then it is necessary to lower the dose.
Side effects
The most common side effects of exemestane are skin rash, nausea, abdominal pain, fatigue, dizziness, headache, insomnia, and emotional distress.
Precautions while taking the drug
Before using Exemestane, it is necessary to conduct a preliminary blood test. This results in a colossal reduction in estradiol and an increase in the efficiency of your cycle. Exemestane is an antiestrogen and is commonly used as part of a PCT.
Compatibility with other drugs
Exemestane is most effective during PCT but may be used in combination with clomiphene or other steroids as part of a cycle.
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