Pregnyl 1500 iu (in box 3 vials HCG & 3 vials solvent)

Pregnyl 1500 iu by MSD pharmaceuticals is in increasing demand among athletes every year. Its use in sports is justified for various purposes, but is usually used as a support after a course of steroids (to promote fitness and prevent side effects).

Pregnyl 1500 iu (Human Chorionic Gonadotropin) is a drug that is a hormone produced by the placenta during pregnancy. It has similar properties to luteinizing hormone and follicle-stimulating hormone (a gonadotropic hormone produced mainly in the pituitary gland).

Physiology of gonadotropin

In the body, the regulation of the level of gonadotropin occurs by a feedback mechanism in the hypothalamus-pituitary-testes axis:

• gonadoliberin is produced in the hypothalamus and stimulates the release of gonadotropic hormones;
• gonadotropins are produced in the pituitary gland and normally stimulate the work of the testicles, with their deficiency, testicular atrophy occurs;
• testosterone and anabolic steroids inhibit the production of GnRH and gonadotropins, resulting in testicular atrophy.

Thus, in bodybuilding, with long-term use of anabolic steroids, it is necessary to additionally introduce gonadotropic hormone (chorionic gonadotropin) in order to prevent testicular atrophy.

Effects of taking Pregnyl

After the introduction of chorionic gonadotropin into the body, this substance begins to act akin to luteinizing hormone. The main effects of this drug include:

1. stimulates the synthesis of sex hormones in the testicles, therefore it has the same range of effects as testosterone;
2. stimulates spermatogenesis;
3. enhances the development of the genital organs and secondary sexual characteristics;
4. in women, it stimulates the production of progesterone by the corpus luteum, provokes ovulation, and supports the development of the placenta.

Women use gonadotropin in the presence of such diseases:

1. infertility;
2. ovarian dysfunction;
3. ovulation induction;
4. amenorrhea;
5. disruption of follicle maturation.

For medical purposes, human chorionic gonadotropin is used by men and women with reproductive health problems. Before you start taking this drug, you must always consult with your doctor.

Application and dosage of Pregnyl

In bodybuilding, perhaps only one property of gonadotropin is valued - an increase in the secretion of sex hormones (testosterone) by the testicles. As a result, gonadotropin is used as a means for the prevention of testicular atrophy and as a component of PCT.

The use of HCG for anabolic purposes is not justified and dangerous to health. Chorionic gonadotropin is less effective than anabolic steroids, and as a result, in order to obtain a good effect, it becomes necessary to use it in large doses (more than 4000 IU per week), which can cause irreversible disturbances in the physiological axis of the hypothalamus-pituitary-testicles. In connection with this circumstance, many articles speak negatively about HCG, forgetting about its true purpose.

Application protocols by Michael Scally MD and Eric Potratz

If the duration of the course does not exceed 5-6 weeks, 1 drug is used in small doses, then there is no need for gonadotropin. If the duration of the course is more than 6 weeks (8-12 weeks), the dosage is too high, 2 or more drugs are used: at least the last 3-5 weeks of the course, perform 2 injections of gonadotropin per week, 250-500 IU, to prevent testicular atrophy. The introduction stops after the almost complete elimination of the anabolic drug, then post-cycle therapy begins. On multi-month courses, gonadotropin is administered continuously, 3-5 weeks after 1-2 weeks (it is necessary to take a break for at least 1-2 weeks in order to prevent desensitization). According to the latest scientific data, this scheme is recognized as optimal, since it allows you to save the function of the testicles and contributes to the most complete recovery after the course.

If HCG has not been used for a long or "heavy" course, then it should be included in the post-cycle therapy, but then it should be used only at the beginning of PCT. The most commonly used blust protocol according to the book by William Llewellyns (Program for Wellness Restoration) is supported by clinical trials, according to which HCG is recommended to be used as part of post-cycle therapy at 2000 IU, every other day for 20 days to restart the hypothalamic-pituitary-testes arc; such a scheme is highly discouraged in the absence of complications.

Side effects

When taking HCG, the same side effects can occur as when taking testosterone. The use of gonadotropin in high doses or for a long time leads to suppression of the secretion of gonadotropin-releasing hormone, and therefore the function of the physiological axis of the hypothalamus-pituitary-testis is impaired. Large doses (2000-5000 IU) are not recommended for longer than 20 days, although according to Michael Scally, MD and a number of studies provided, testicular desensitization does not occur if the dosage does not exceed 500 IU or hCG is administered less than 3 times a week. This protocol can be considered safe even for 1-2 months.

The information that gonadotropin can lead to pregnancy symptoms in men is completely absurd and untrue.